The exchange of health data is of continued importance in the global response to the COVID-19 pandemic. This fact reminds us of the essential roles that data and technology play in our lives. Health information exchange and interoperability are integral components of healthcare systems around the world. In this commentary, the concepts of health information exchange and interoperability are discussed, and two examples are briefly described. We present issues for health system decision-makers to consider as they move toward adopting health information exchanges and interoperability with a health system to support population health management.