Abstract

Glutamine in Critically ill Patients – When and How?

Author(s): Khaled Sewify

EN contains little glutamine that inadequate to normalize the plasma level and PN doesn’t contain glutamine because, it is unstable in aqueous solutions that is why IV Glutamine supplementation stayed for decades, a standard of care whenever TPN is prescribed. Recent practices focus on pharmaco-nutrition especially when feeding critically ill patients, that why many meta-analysis tried to figure out whether glutamine works or not? Although glutamine is generally well tolerated and adverse events are very rare, better identification of the ideal characteristics of effective glutamine coupled with improved understanding of mechanisms of action will help to delineate the true beneficial effects of glutamine in various disorders. This review highlights current practice and areas of concern and establishes our current knowledge in this field. PDF